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pentobarbital will lessen the level or influence of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the extent or outcome of loratadine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will lessen the extent or effect of colchicine